Proteostasis
Proteostasis
Heat shock proteins, ubiquitin-proteasome pathway, and protein quality control tools — reagents for studying protein folding, degradation, and aggregation in health and disease.
Maintaining the Proteome
Proteostasis — the homeostatic maintenance of the proteome — is essential for cellular health and is disrupted in neurodegenerative diseases, cancer, aging, and metabolic disorders. This intricate network encompasses molecular chaperones (heat shock proteins), the ubiquitin-proteasome system, autophagy-lysosome pathway, and the unfolded protein response. Enzo Life Sciences is a recognized leader in proteostasis research tools, offering one of the industry's broadest portfolios of HSP antibodies and activity assays, ubiquitin pathway reagents, proteasome activity kits, and protein aggregation detection tools.
Heat Shock Protein Detection
Industry-leading portfolio of HSP antibodies, ELISA kits, and activity assays covering HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110 families. Our StressXpress ELISA kits provide sensitive, quantitative measurement of HSP levels in cell lysates, serum, and tissue samples.
Ubiquitin-Proteasome Pathway
Comprehensive reagents for ubiquitin detection (mono- and poly-Ub antibodies, UBIQapture affinity matrices), E1/E2/E3 enzyme activity assays, deubiquitinase (DUB) substrates, and ubiquitin chain-specific antibodies (K48, K63, linear). Study protein turnover and signaling through ubiquitination.
Proteasome Activity Assays
Fluorogenic substrate-based kits measuring chymotrypsin-like, trypsin-like, and caspase-like activities of the 20S and 26S proteasome. Our Proteasome Activity Assay Kit is validated for cell lysates, tissue homogenates, and purified proteasome preparations.
Protein Aggregation & ER Stress
Detect misfolded protein aggregates with our PROTEOSTAT Aggresome Detection Kit — the most cited protein aggregation fluorescent assay. Combined with ER stress markers (BiP/GRP78, CHOP, IRE1α, ATF6) for comprehensive unfolded protein response analysis.
Proteostasis — By the Numbers
Explore proteostasis research tools
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