Epigenetics
Epigenetics
DNA methylation analysis, histone modification detection, and epigenetic enzyme assays — tools for chromatin biology, gene silencing, and epigenetic drug discovery.
Decoding the Epigenome
Epigenetics — heritable changes in gene expression without alterations to DNA sequence — governs development, cellular identity, and disease susceptibility. DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA regulation work in concert to control which genes are active in each cell type. Enzo Life Sciences provides epigenetics researchers with validated tools for DNA methylation quantification, histone modification detection, epigenetic enzyme activity measurement, and small molecule compound libraries targeting epigenetic regulators for drug discovery.
DNA Methylation Analysis
Global DNA methylation ELISA kits (5-mC and 5-hmC quantification), methylated DNA immunoprecipitation reagents, and DNMT activity assays. Measure DNA methylation levels in genomic DNA from cells, tissues, and clinical samples with colorimetric and fluorometric detection options.
Histone Modification Antibodies
Validated antibodies for histone H3 and H4 modifications — acetylation (H3K9ac, H3K27ac, H4K16ac), methylation (H3K4me3, H3K9me3, H3K27me3, H3K36me3), phosphorylation (H3S10ph), and ubiquitination (H2AK119ub). ChIP-validated and suitable for Western blot, IF, and IHC.
Epigenetic Enzyme Assays
Activity assays for HDACs (class I, II, III/sirtuins), HATs, histone methyltransferases (HMTs), histone demethylases (HDMs), and DNMTs. Fluorogenic substrate-based kits compatible with purified enzymes, nuclear extracts, and cell lysates for inhibitor screening and mechanistic studies.
Epigenetic Compound Libraries
SCREEN-WELL Epigenetics Library with annotated HDAC inhibitors, DNMT inhibitors, BET bromodomain inhibitors, EZH2 inhibitors, and other epigenetic modulators. Pre-plated for 96-well screening with detailed target, potency, and selectivity annotations.
Epigenetics — By the Numbers
Explore epigenetics research tools
Explore our curated product selection for this research area or contact our scientific support team for personalized recommendations.