Genotoxicity Testing

Comprehensive DNA damage detection and mutagenicity screening tools — supporting cosmetic ingredient safety assessment with validated in vitro genotoxicity endpoints.

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DNA Damage & Mutagenicity Assessment

Genotoxicity testing is a critical component of cosmetic ingredient safety evaluation under EU Cosmetics Regulation (EC 1223/2009) and global regulatory frameworks. Enzo Life Sciences offers a comprehensive portfolio of assay kits for detecting DNA strand breaks, oxidative DNA damage, chromosomal aberrations, and mutagenic potential — enabling cosmetic companies to screen ingredients and finished products using in vitro methods that reduce reliance on animal testing.

Oxidative DNA Damage (8-OHdG)

Our 8-OHdG ELISA kit provides sensitive quantification of 8-hydroxy-2'-deoxyguanosine, the most widely used biomarker of oxidative DNA damage. Detect genotoxic potential at concentrations as low as 0.59 ng/mL in cell lysates, urine, and culture supernatants.

8-OHdG

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DNA Damage Response Markers

Antibodies and assay kits for γH2AX, p53, ATM/ATR pathway components, and other DNA damage response (DDR) markers. These endpoints enable mechanistic assessment of genotoxic pathways activated by cosmetic ingredients.

DDR

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Comet Assay Reagents

High-purity reagents for the alkaline comet assay (single cell gel electrophoresis), including low-melting-point agarose, lysis buffers, and SYBR-based DNA stains for fluorescence microscopy detection of DNA strand breaks.

Comet

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Cell Cycle & Apoptosis Analysis

Flow cytometry-compatible kits for cell cycle distribution analysis and apoptosis detection. Annexin V-FITC/PI kits, caspase activity assays, and TUNEL reagents enable assessment of genotoxin-induced cell death pathways.

Apoptosis

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