Endocrine Disruption
Endocrine Disruption Testing
Screen cosmetic ingredients for endocrine-disrupting potential — validated hormone receptor assays, steroidogenesis markers, and thyroid function endpoints.
Detecting Hormonal Activity in Personal Care Ingredients
Growing regulatory scrutiny of endocrine-disrupting chemicals (EDCs) in personal care products demands robust screening tools. The EU Cosmetics Regulation and REACH require assessment of endocrine-disrupting potential for cosmetic ingredients. Enzo Life Sciences provides sensitive immunoassay kits for measuring hormone levels, receptor binding activity, and steroidogenesis modulation — enabling personal care companies to screen ingredients for estrogenic, androgenic, thyroid-disrupting, and steroidogenic activity using validated in vitro approaches.
Estrogen & Androgen Receptor Activity
ELISA-based detection of estradiol, testosterone, and receptor binding activity for screening estrogenic and androgenic compounds. Our kits detect hormone levels in cell culture supernatants with sensitivity suitable for low-dose exposure assessment in accordance with OECD TG 455 and 458 frameworks.
Steroidogenesis Assays
Measure cortisol, DHEA, progesterone, and other steroid hormone production in H295R adrenocortical cell models. These endpoints support OECD TG 456 (H295R Steroidogenesis Assay) for detecting chemicals that alter steroid hormone synthesis pathways.
Thyroid Function Markers
Quantitative ELISA kits for TSH, T3, T4, and thyroid peroxidase (TPO) activity assessment. Detect thyroid-disrupting potential of personal care ingredients that may interfere with iodine uptake, hormone synthesis, or hormone transport.
Aromatase & 5α-Reductase Activity
Fluorometric and ELISA-based assays for aromatase (CYP19) and 5α-reductase enzyme activity. Screen ingredients for their ability to modulate key enzymes in steroid hormone metabolism — critical endpoints for comprehensive endocrine disruption assessment.
Featured Products
Explore our most popular kits and reagents for this application area:
- Estradiol ELISA Kit
- Testosterone ELISA Kit
- Cortisol ELISA Kit
- Progesterone ELISA Kit
- TSH ELISA Kit
Endocrine Disruption Testing — By the Numbers
Assess Endocrine Safety of Your Ingredients
Contact our team to discuss your testing requirements or request product recommendations for your specific application.