Allergy & Inflammation Testing

Comprehensive assessment of allergenic and inflammatory potential — skin sensitization markers, histamine release, cytokine profiling, and prostaglandin quantification.

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Immune Response & Sensitization Assessment

Allergic contact dermatitis is among the most common adverse reactions to personal care products. Enzo Life Sciences provides validated tools for assessing the skin sensitization, allergenic, and pro-inflammatory potential of cosmetic ingredients using in vitro methods aligned with the OECD Adverse Outcome Pathway (AOP) for skin sensitization. From direct peptide reactivity and keratinocyte activation to dendritic cell maturation and T-cell response markers, our assays cover every key event in the sensitization pathway.

Skin Sensitization (OECD AOP)

Assay tools supporting key events in the skin sensitization AOP: KE1 (covalent binding to proteins — peptide reactivity), KE2 (keratinocyte activation — Nrf2/ARE pathway, IL-18), KE3 (dendritic cell activation — CD86, CD54, IL-8), and KE4 (T-cell proliferation markers).

AOP

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Histamine & Mast Cell Mediators

Sensitive ELISA kits for histamine, tryptase, and leukotriene quantification. Measure mast cell degranulation and immediate-type hypersensitivity responses triggered by cosmetic ingredients in cell-based release assays.

Histamine

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Inflammatory Cytokine Profiling

Comprehensive ELISA panels for IL-1α, IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-18, TNF-α, and IFN-γ. Profile the complete Th1/Th2 cytokine response to evaluate both irritant and allergic inflammatory mechanisms.

Cytokines

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Prostaglandin & Eicosanoid Assays

ELISA kits for PGE2, PGD2, PGF2α, thromboxane B2, and leukotriene B4/C4/E4 quantification. Assess the arachidonic acid cascade activation and anti-inflammatory potential of cosmetic ingredients with picogram-level sensitivity.

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