Additional Safety & Toxicity Testing

Beyond standard endpoints — phototoxicity, eye irritation, organ-specific toxicity, and systemic safety assessment tools for comprehensive ingredient evaluation.

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Comprehensive Toxicity Profiling

A thorough safety assessment of personal care ingredients extends beyond skin irritation and genotoxicity. Enzo Life Sciences provides validated assay kits for phototoxicity evaluation, ocular irritation alternatives, hepatotoxicity markers, nephrotoxicity endpoints, and systemic toxicity indicators. Our tools support the integrated testing strategies (ITS) and defined approaches recommended by regulatory agencies for comprehensive ingredient safety evaluation.

Phototoxicity Assessment

Cell viability and ROS-based assays compatible with the 3T3 NRU phototoxicity test (OECD TG 432). Evaluate UV-induced cytotoxicity and photoirritation potential of cosmetic ingredients with quantitative dose-response measurement.

Photo

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Ocular Safety Testing

In vitro eye irritation alternatives including cytotoxicity assays on corneal epithelial cell models and fluorescein leakage assays. Support OECD TG 492 (reconstructed cornea-like epithelium) and TG 460 (fluorescein leakage) testing strategies.

Ocular

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Organ-Specific Toxicity Markers

ELISA kits and biomarker panels for hepatotoxicity (ALT, AST, GLDH), nephrotoxicity (KIM-1, NGAL, cystatin C), and cardiotoxicity (troponin, BNP) enabling early detection of organ-specific adverse effects in preclinical screening.

Organ

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Mitochondrial Toxicity

Assays for mitochondrial membrane potential, ATP production, and respiratory chain complex activity. Detect mitochondrial dysfunction as an early indicator of cellular toxicity before overt cell death occurs.

Mito

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