Proteostasis
Proteostasis
Protein folding, quality control, and degradation tools — from molecular chaperones and the ubiquitin-proteasome system to autophagy-lysosome pathways.
Maintaining the Cellular Protein Balance
Proteostasis — the homeostatic maintenance of the proteome — is essential for cellular health and is disrupted in neurodegenerative diseases, cancer, and aging. Enzo Life Sciences is a pioneer in proteostasis research tools, offering the industry's broadest portfolio of heat shock protein antibodies and assays, ubiquitin pathway reagents, proteasome activity kits, and protein aggregation detection tools. Our products support research across the entire proteostasis network, from co-translational folding through degradation.
Proteostasis Research Areas
Key product categories for proteostasis research
Heat Shock Proteins
Antibodies and ELISA kits for Hsp27, Hsp40, Hsp60, Hsp70, Hsp90, and small HSPs. Validated for Western blot, IHC, ICC, flow cytometry, and functional studies of the chaperone network.
Ubiquitin Pathway
Ubiquitin antibodies (K48, K63, linear), E1/E2/E3 enzyme reagents, DUB activity assays, and ubiquitin chain tools for studying protein ubiquitination and proteasomal targeting.
Proteasome Assays
Fluorogenic substrates for measuring 20S/26S proteasome activity (chymotrypsin-like, trypsin-like, caspase-like), proteasome inhibitors, and activity-based probes.
HSP70 & HSP90 Research Portfolio
Enzo's heat shock protein portfolio is the most extensively cited in the field. Our anti-Hsp70 (C92F3A-5) and anti-Hsp90 antibodies have been validated across thousands of publications. We offer ELISA kits for serum/plasma Hsp70 quantification, recombinant HSP proteins for functional studies, and small molecule HSP inhibitors for pathway modulation. This comprehensive toolkit enables research from basic stress response biology through translational biomarker discovery.
Explore Proteostasis Research Tools
Explore our curated product selection for this research area or contact our scientific support team for personalized recommendations.